Binary fission:
1. Two new individuals are formed from one old individual at one time.
2. The division of nucleus and cytoplasm takes place initially.
3. The axis of division can be transverse, longitudinal or any one axis as it is in simple binary fission.
4. Formation of protective cyst does not take place.
5. Binary fission can be done during favourable period.
Multiple fission:
1. Many new individuals are formed from one old individual at one time.
2. Only nucleus divides initially followed by division of cytoplasm.
3. There is no exact axis for the fission.
4. Protective covering is formed around dividing amoebulae which is called cyst.
5. Multiple fission takes place only at the time of unfavourable period.
